- H Pylori Bacteria - Smoking Facts About Helicobacter Pylori Infection
H pylori bacteria are now known to be the cause of stomach ulcer.
The full name of the bacteria is helicobacter pylori.
The smoking facts reveal that smokers are more resistant to treatment of helicobacter pylori infection
and therefore they are more susceptible to gastric (stomach) cancer.
This may be because of the overall negative health effects of smoking cigarettes on immune
system function.
Helicobacter Pylori Infection as the Cause of Stomach Ulcer
Up until the 1980s it was thought that stomach ulcers were caused by spicy food, acid, or stress. At that time the current epidemiological evidence showed a greater risk for
stomach ulcer among smokers than among non-smokers.
Today infection with bacteria is the model that explains the cause of stomach ulcer
and the organism that causes that infection has been identified as helicobacter pylori.
It is estimated that 80 percent of gastric ulcers and 90 percent of duodenal ulcers are caused by the helicobacter pylori infection.
Some people can have helicobacter pylori in their stomach and not have any adverse effects.
However in some individuals the presence of the bacteria weakens the natural protective coating
inside the stomach.
This allows the stomach acid to literally digest the tissue causing an ulcer.
As the bacteria and the stomach acid irritate this sore it gets larger and larger eroding through the stomach tissue.
If the ulcer gets large enough to perforate the stomach or if it opens a blood vessel it can be a life threatening situation.
Seeking the Smoking Facts about H Pylori Bacteria
Despite the discovery of this new bacteria and the radical shift in thinking about the cause of
stomach ulcer, the epidemiological evidence persists that
smokers are more vulnerable to gastric ulcers. So scientists
have been seeking a link between the negative gastric effects of smoking cigarettes and
the presence of H pylori bacteria.
In 1993 a study published in the UK1 confirmed the hypothesis that
H pylori bacteria was more common among smokers. The results supported the hypothesis that smokers are
predisposed to peptic ulcers and that susceptibility to infection with H. pylori bacteria was one of the health effects of smoking cigarettes.
Subsequent studies however, did not prove this to be the case consistently.2
In some studies treatment of H pylori bacteria has been found to be less successful in smokers,3 whereas
in other studies using different treatment regimes, the differences in treatment outcome between
smokers and non smokers was found to be very small.4
Really it is enough to make your head spin. First smokers are more at risk for helicobacter pylori
infection, then they are not.
The body of evidence that is emerging however seems to favour the former statement and not the latter.
"Our meta-analysis demonstrated that smoking increases the treatment failure rate for H. pylori eradication."3
"Tobacco smoking and H. pylori are both risk factors in the development of gastric cancer, and tobacco smoking is still a risk factor among H. pylori-infected individuals. The risk of gastric cancer among H. pylori-infected current smokers is 11 times that of non-infected individuals not currently smoking.5"
"Generally, smokers were found to have a statistically significant higher risk (risk ratio = 5.3) of H. pylori infection than nonsmokers.6"
While there are some studies that do not support these results they are isolated studies and much fewer in number that those that show smokers are more vulnerable to H pylori infection. Over time the smoking facts will become more solid as more studies confirm or disprove the relationship.
In the meantime it is known that there are many gastrointestinal health effects of smoking cigarettes and they are all negative,
so it is entirely plausible that H pylori bacteria can do more damage in a smoker than a non smoker.
1. Bateson M C Cigarette smoking and H Pylori infection. Postgrad Med J. 1993 January; 69(807): 41-44.
2. Ogihara, A et al Relationship between Helicobacter pylori infection and smoking and drinking habits Journal of Gastroenterology and Hepatology, Volume 15, Number 3, March 2000 , pp. 271-276(6)
3. Suzuki et al Smoking Increases the Treatment Failure for Helicobacter pylori Eradication Volume 119, American Journal of Medicine Issue 3, Pages 217-224 (March 2006)
4. Bardhan, K et al The Effects of Smoking on Cure of Helicobacter pylori Infection and Duodenal Uulcer Recurrence in Patients Treated with Clarithromycin and Omeprazole
Helicobacter. March 1997 Volume 2, Issue 1 Pages 1-55
5. Siman J H,Forsgren A,Berglund G,Floren C H. Tobacco Smoking Increases the Risk for Gastric Adenocarcinoma among Helicobacter pylori-infected Individuals Scandinavian Journal of Gastroenterology
2001, Vol. 36, No. 2 , Pages 208-213
6. El Barrawy M, Morad M, and Gaber M. Role of Helicobacter pylori in the genesis of gastric ulcerations among smokers and nonsmokers East Mediterranean Health Journal. Volume 3, Issue 2, 1997, Page 316-321
The purpose of the information provided here is to help you cooperate with your doctor and other
health practitioners. It is not intended to take the place of medical advice and you are encouraged to
discuss health concerns with your physician or a professional health care provider who is
familiar with you and your unique personal health context.